Title:
肝細胞増殖因子（ＨＧＦ）のＰＤマーカー
Document Type and Number:
Japanese Patent JP6800208
Kind Code:
B2
Abstract:
The present invention provides a method for evaluating the pharmacological action of HGF that utilizes a PD marker in which fluctuation is recognized by administration of hepatocyte growth factor (HGF) in a broader range of subjects. A method for evaluating the pharmacodynamic action of HGF is provided. The aforementioned evaluation method is characterized in that it comprises a step of measuring the ApoA4 level in a biological sample collected from a test subject who was administered HGF. According to the present invention, a kit for evaluating the pharmacodynamic action of HGF comprising an anti-ApoA4 antibody is further provided.
Inventors:
Kimura May
Sotaro Motoi
Takashi Ohara
Moriya Katsuhiro
Hideaki Ogasawara
Takahisa Arita
Kono Tetsu
Sotaro Motoi
Takashi Ohara
Moriya Katsuhiro
Hideaki Ogasawara
Takahisa Arita
Kono Tetsu
Application Number:
JP2018505994A
Publication Date:
December 16, 2020
Filing Date:
March 16, 2017
Export Citation:
Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
G01N33/53; C07K14/475; C12Q1/6851; C12Q1/686
Domestic Patent References:
| JP10167982A | ||||
| JP2012051822A |
Foreign References:
| WO2012144535A1 | ||||
| WO2013018851A1 |
Other References:
太田稔 ほか,肝細胞癌患者において肝動脈塞栓術(TAE)施行後のヒト肝細胞増殖因子(hHGF)とアポリポ蛋白A-IVの血中濃度変化,臨牀と研究,1994年 8月,第71巻,第8号,pp.2197-2199
XU, X. et al.,Transcriptional regulation of apolipoprotein A-IV by the transcription factor CREBH,JOURNAL OF LIPID RESEARCH,2014年 5月 1日,vol. 55, no. 5,pp.858-859
KOSONE, K. et al.,HGF ameliorates a high-fat diet-induced fatty liver,AMERICAN JOURNAL OF PHYSIOLOGY GASTROINTESTINAL AND LIVER PHYSIOLOGY,2007年 3月29日,vol. 293, no. 1,pp. G204-G210
KAIBORI, M. et al.,Hepatocyte growth factor stimulates synthesis of lipids and secretion of lipoproteins in rat hepatocytes,HEPATOLOGY,1998年 5月 1日,vol. 27, no. 5,pp. 1354-1361
XU, N. et al.,Transforming growth factor-beta down-regulates apolipoprotein M in HepG2 cells,BIOCHIMICA ET BIOPHYSICA ACTA,2004年 4月28日,vol. 1683,pp. 33-37
XU, X. et al.,Transcriptional regulation of apolipoprotein A-IV by the transcription factor CREBH,JOURNAL OF LIPID RESEARCH,2014年 5月 1日,vol. 55, no. 5,pp.858-859
KOSONE, K. et al.,HGF ameliorates a high-fat diet-induced fatty liver,AMERICAN JOURNAL OF PHYSIOLOGY GASTROINTESTINAL AND LIVER PHYSIOLOGY,2007年 3月29日,vol. 293, no. 1,pp. G204-G210
KAIBORI, M. et al.,Hepatocyte growth factor stimulates synthesis of lipids and secretion of lipoproteins in rat hepatocytes,HEPATOLOGY,1998年 5月 1日,vol. 27, no. 5,pp. 1354-1361
XU, N. et al.,Transforming growth factor-beta down-regulates apolipoprotein M in HepG2 cells,BIOCHIMICA ET BIOPHYSICA ACTA,2004年 4月28日,vol. 1683,pp. 33-37
Attorney, Agent or Firm:
Masahiro Nanjo
Ayako Seta
Koichiro Inami
Hidetoshi Hara
Ayako Seta
Koichiro Inami
Hidetoshi Hara