Title:
２−アセチル−４Ｈ，９Ｈ−ナフト［２，３−ｂ］フラン−４，９−ジオンの製造方法
Document Type and Number:
Japanese Patent JP6810036
Kind Code:
B2
Abstract:
The invention addresses the problem of providing a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione that is suited to industrial production. The invention provides a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by reacting 3-bromo-3-buten-2-one and 2-hydroxy-1,4-naphthoquinone in the presence of a solvent, then obtaining crystals of 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by adding an alcohol-based solvent and/or water to the reaction system, and treating the crystals by using a specific adsorbent in the presence of a solvent.
Inventors:
Shunichi Yagi
Satoshi Suzuki
Kato Tatani
Kazuki Hashimoto
Satoshi Suzuki
Kato Tatani
Kazuki Hashimoto
Application Number:
JP2017529452A
Publication Date:
January 06, 2021
Filing Date:
July 15, 2016
Export Citation:
Assignee:
Sumitomo Dainippon Pharma Co., Ltd.
International Classes:
C07D307/92
Domestic Patent References:
| JP2013522325A | ||||
| JP2014511384A | ||||
| JP2010539097A | ||||
| JP2015506990A | ||||
| JP2010111629A | ||||
| JP2008162985A | ||||
| JP11180914A | ||||
| JP4312567A |
Foreign References:
| WO2014169078A1 | ||||
| WO2013166618A1 |
Other References:
実験化学講座(続)2 分離と精製,丸善株式会社,1967年 1月25日,p.159-178,186-187
溶剤ハンドブック,株式会社講談社,1985年 9月 1日,p.156-158,p.186-189,292-294,350-352,450-451,568-571,578-579,642-647
HAGIWARA Hisahiro, et al.,Domino Michael-O-alkylation reaction: one-pot synthesis of 2,4-diacylhydrofuran derivatives and its,Journal of the Chemical Society, Perkin Transactions 1,2001年,Vol.22,p.2946-2957
HIGGINS Catherine A., et al.,Growth inhibitory activity of extracted material and isolated compounds from the fruits of Kigelia p,Planta Medica,2010年,Vol.76(16),p.1840-1846
溶剤ハンドブック,株式会社講談社,1985年 9月 1日,p.156-158,p.186-189,292-294,350-352,450-451,568-571,578-579,642-647
HAGIWARA Hisahiro, et al.,Domino Michael-O-alkylation reaction: one-pot synthesis of 2,4-diacylhydrofuran derivatives and its,Journal of the Chemical Society, Perkin Transactions 1,2001年,Vol.22,p.2946-2957
HIGGINS Catherine A., et al.,Growth inhibitory activity of extracted material and isolated compounds from the fruits of Kigelia p,Planta Medica,2010年,Vol.76(16),p.1840-1846
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takeshi Komatani
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takeshi Komatani
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto