Title:
ポリフェノール化合物を有効成分として含む癌治療用薬学組成物
Document Type and Number:
Japanese Patent JP6829723
Kind Code:
B2
Abstract:
The present invention relates to a pharmaceutical composition for treating cancer, containing a polyphenol compound as an active ingredient. The pharmaceutical composition according to the present study is very effective for the treatment and prognosis-improvement of cancer stem cells or cancer tissues having a magnitude of cancer stem cells such as poorly differentiated cancer. Further, the polyphenol compound and a biguanide compound, and an anticancer agent were observed to remarkably increase inhibitory effects on the growth of cancerous cells when they were administered to cancerous cells in combination rather than individually, thus the composition is expected to find great applications in the cancer therapy field.
Inventors:
Jeong, Cheho
Kim, Suyeol
Kim, Suyeol
Application Number:
JP2018536492A
Publication Date:
February 10, 2021
Filing Date:
February 17, 2017
Export Citation:
Assignee:
Industry-Academic Co-Operation Foundation, Yonsei University
National Cancer Center
National Cancer Center
International Classes:
A61K31/11; A61K31/155; A61K31/4745; A61P35/00; A61P35/04
Domestic Patent References:
| JP2017506655A | ||||
| JP2010529023A |
Foreign References:
| WO2015130109A1 | ||||
| US6114397 |
Other References:
Proc. Natl. Sci. USA, 2014, Vol.111, No.29, pp.10574-10579
Cancer Biol. Ther., 2015, Vol.16, No.1, pp.77-87
Science, 2011, Vol.331, No.6016, pp.456-461
Oncotarget, 2011, Vol.2, No.12, pp.896-917
Cancer Biol. Ther., 2015, Vol.16, No.1, pp.77-87
Science, 2011, Vol.331, No.6016, pp.456-461
Oncotarget, 2011, Vol.2, No.12, pp.896-917
Attorney, Agent or Firm:
Patent Business Corporation Unias International Patent Office