Title:
左室駆出率が保たれた心不全を治療するための方法及び組成物
Document Type and Number:
Japanese Patent JP6832401
Kind Code:
B2
Abstract:
A pharmaceutical composition for treatment of persons afflicted of heart failure with preserved ejection fraction (HFPEF), diastolic heart failure (DHF) or diastolic dysfunction (DF), the composition comprising a therapeutically effective amount of a compound capable of specific binding to the relaxin receptor (RXFP1) present on fibroblasts, fibromyoblasts, endothelial cells, endocardial cells, and cardiomyocytes in the cardiac muscle to increase the heart's stroke volume at lower end-diastolic pressure.
Inventors:
Deshetzig, Thomas
Application Number:
JP2019155391A
Publication Date:
February 24, 2021
Filing Date:
August 28, 2019
Export Citation:
Assignee:
Relaxera Pharmazoisit Gesellschaft Mbeha und Co.
International Classes:
A61K38/22; A61K9/107; A61P9/04
Domestic Patent References:
| JP2017517524A |
Foreign References:
| WO2013017679A1 |
Other References:
Pharmacology and Therapeutics,2006年,Vol.112,p.529-552
Journal of Hypertension,2012年,Vol.30, e-Supplement 1,Abstract No.882
Journal of Hypertension,2012年,Vol.30, e-Supplement 1,Abstract No.882
Attorney, Agent or Firm:
Atsushi Nakajima
Kato Kazunori
Kato Kazunori