Title:
ラパマイシン誘導体を含有する固体分散体の製造方法
Document Type and Number:
Japanese Patent JP6857663
Kind Code:
B2
Abstract:
It is an object of the present invention to provide a solid dispersion, which suppresses a reduction in the content of an active ingredient caused by oxidation or decomposition of rapamycin or a derivative thereof, can ensure long-term stability, and has high safety. According to the present invention, there is provided a method for producing a solid dispersion comprising, as an active ingredient, rapamycin or a derivative thereof, wherein the method comprises: a first step of mixing a first solvent that is a protic polar solvent, a second solvent that is an aprotic solvent, a water-soluble polymeric carrier, and rapamycin or a derivative thereof, wherein the ratio of the first solvent is higher than 50% by volume of the total volume of the first solvent and the second solvent; and a second step of removing the solvents.
Inventors:
Kawamura Dai
Application Number:
JP2018543916A
Publication Date:
April 14, 2021
Filing Date:
October 03, 2017
Export Citation:
Assignee:
NIPPON KAYAKU KABUSHIKI KAISHA
International Classes:
A61K31/436; A61K9/14; A61K9/20; A61K47/22; A61K47/26; A61K47/38; A61P1/00; A61P1/16; A61P3/10; A61P5/00; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P21/04; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00
Domestic Patent References:
| JP11509223A |