Title:
ＣＯＭＴ阻害方法及び組成物
Document Type and Number:
Japanese Patent JP6858712
Kind Code:
B2
Abstract:
The present inventions include a method of inhibiting COMT enzyme in a subject as well as compounds of formula I, or a pharmaceutically acceptable salt thereof, that are useful in the treatment of various disorders mediated by COMT, including Parkinson's disease and/or schizophrenia.
Inventors:
Barrow James
Ernst Glen
Fan efan
Bushler Ingrid
Wine burger daniel
Ernst Glen
Fan efan
Bushler Ingrid
Wine burger daniel
Application Number:
JP2017559273A
Publication Date:
April 14, 2021
Filing Date:
January 29, 2016
Export Citation:
Assignee:
LIEBER INSTITUTE FOR BRAIN DEVELOPMENT
International Classes:
A61K31/4709; A61K31/47; A61K31/496; A61K31/5377; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P25/30; A61P43/00; C07D215/24; C07D401/12; C07D401/14; C07D417/12; C07D471/04; C07D471/10
Other References:
Bioorganic & Medicinal Chemistry,2014年 6月18日,Vol.22,P.3891-3905,特にAbstract, 化合物5, 7, 11
Chem. Mater.,1996年,Vol.8,P.344-351,特にFigure2の化合物1
Chem. Mater.,1996年,Vol.8,P.344-351,特にFigure2の化合物1
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Satoshi Morikawa
Hiroyuki Tomita
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Satoshi Morikawa
Hiroyuki Tomita