Title:
ＦｃＲｎ結合特性が改変されているＦｃ領域変異体
Document Type and Number:
Japanese Patent JP6873701
Kind Code:
B2
Abstract:
Herein is reported a polypeptide comprising a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a portion of an immunoglobulin hinge region, which comprises one or more cysteine residues, an immunoglobulin CH2-domain and an immunoglobulin CH3-domain, wherein i) the first and the second polypeptide comprise the mutations H310A, H433A and Y436A, or ii) the first and the second polypeptide comprise the mutations L251D, L314D and L432D, or iii) the first and the second polypeptide comprise the mutations L251S, L314S and L432S.
Inventors:
Schlothauer, Tillman
Application Number:
JP2016546942A
Publication Date:
May 19, 2021
Filing Date:
January 12, 2015
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07K16/46; A61K39/395; A61P27/02; A61P43/00; C07K16/12
Domestic Patent References:
| JP2012524528A |
Foreign References:
| WO2014006217A1 | ||||
| US6277375 | ||||
| WO2013004842A1 |
Other References:
The Journal of Biological Chemistry,2001年,Vol.276, No.9,p.6591-6604
The Journal of Immunology,1997年,Vol.158, No.5,p.2211-2217
European Journal of Immunology,1999年,Vol.29,p.2819-2825
Molecular Cell,2001年,Vol.7,p.867-877
The Journal of Immunology,1997年,Vol.158, No.5,p.2211-2217
European Journal of Immunology,1999年,Vol.29,p.2819-2825
Molecular Cell,2001年,Vol.7,p.867-877
Attorney, Agent or Firm:
Patent business corporation Tsukuni