Title:
ネオモルフィックＳＦ３Ｂ１変異体に関連するスプライスバリアント
Document Type and Number:
Japanese Patent JP6876680
Kind Code:
B2
Abstract:
Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.
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Inventors:
You, Reefer
Rim, Kian, Hu
Fiara, Jacob, Dee.
Buona Michi, Sylvia
Yoshiharu Mizui
Smith, Peter, Gee.
Zoo pin
Park, Unis, Sun
Sailor, Michael, W.
Feckes, Marco, Peter
Rim, Kian, Hu
Fiara, Jacob, Dee.
Buona Michi, Sylvia
Yoshiharu Mizui
Smith, Peter, Gee.
Zoo pin
Park, Unis, Sun
Sailor, Michael, W.
Feckes, Marco, Peter
Application Number:
JP2018510109A
Publication Date:
May 26, 2021
Filing Date:
August 30, 2016
Export Citation:
Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
C12Q1/6876; A61K45/00; A61P35/00; A61P35/02; C12Q1/02; C12Q1/6841; C12Q1/686; C12Q1/6869; C12Q1/6874
Domestic Patent References:
| JP2013184887A |
Foreign References:
| WO2011129427A1 |
Other References:
Kenichi Yoshida,Frequent pathway mutations of splicing machinery in myelodysplasia,NATURE,2011年,Vol.478,p.64-69
Simon J. Furney,SF3B1 Mutations AreAssociated with Alternative Splicing in Uveal Melanoma,CANCER DISCOVERY,2013年 7月16日,p.1122-1129
Simon J. Furney,SF3B1 Mutations AreAssociated with Alternative Splicing in Uveal Melanoma,CANCER DISCOVERY,2013年 7月16日,p.1122-1129
Attorney, Agent or Firm:
Yoshiki Hasegawa
Yoshinori Shimizu
Kimoto
Sayaka Harada
Yoshinori Shimizu
Kimoto
Sayaka Harada