Title:
化学修飾されたオリゴヌクレオチドを利用する創傷治癒の処置のための方法
Document Type and Number:
Japanese Patent JP6883987
Kind Code:
B2
Abstract:
The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal and fibrotic applications. Aspects of the invention provide nucleic acid molecules for the prophylactic treatment of wounding to reduce scarring. Herein, it is demonstrated that a specific nucleic acid molecule, RXI-109 (targeting connective tissue growth factor (CTGF)), given prophylactically, reduces scarring during wound healing.
Inventors:
Cowenberg, Gerrard
Pavco, Pamela, A.
Libertine, Lynn
Brock, Karen, Gee.
James, Caldia
Pavco, Pamela, A.
Libertine, Lynn
Brock, Karen, Gee.
James, Caldia
Application Number:
JP2016536865A
Publication Date:
June 09, 2021
Filing Date:
December 04, 2014
Export Citation:
Assignee:
Phio Pharmaceuticals Corp.
International Classes:
A61K48/00; A61K31/7115; A61P17/02; A61P27/02
Domestic Patent References:
| JP2013532952A |
Foreign References:
| WO2012106508A1 | ||||
| US20110054004 |
Attorney, Agent or Firm:
Kiyoji Kuzuwa