早期大腸癌の検出方法

Japanese Patent JP6896258

B2

Provided is a method for detecting early colon cancer using the level of a gene in the stool of a subject as an indicator, wherein the method for detecting early colon cancer is characterized in that the gene is at least one selected from the group consisting of the hippurate hydrolase gene, cyclohexadienyl dehydratase gene, butanol dehydrogenase gene, nucleobase:cation symporter-1 gene, and 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase gene.

Takuji Yamada
Masatsugu Fukuda
Shinichi Taniuchida

JP2019569632A

June 30, 2021

February 04, 2019

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National University Corporation Tokyo Institute of Technology
Keio University
National Cancer Research Center

C12Q1/6809; C12Q1/06

YANG, Y. et al.,Atopobium parvulum produces genotoxic H2S and promotes colitis-associated colorectal cancer developm,UFHCC Research Day 2017[online],2017年,Retrieved from the Internet,,URL,https://cancer.ufl.edu/files/gravity_forms/4-af155b3c642dcf454980cf67d1801b5b/2017/10/UFHCC-Research-Day-2017-Abstract-Final6.pdf
谷内田真一 ほか,大腸がんの多段階発がんと腸内環境の変動,日本人類遺伝学会大会プログラム・抄録集,2017年,Vol. 62nd,p. 213
水谷紗弥佳 ほか,腸内メタゲノム・メタボロームデータを用いた大腸がんの腸内細菌叢の解析,日本生化学会大会(Web)[online],2017年11月15日,Vol. 90th,1LBA-042,Retrieved from the Internet,URL,https://www.aeplan.co.jp/conbio2017/
城間博紹 ほか,メタゲノム解析を用いた大腸がん疾病マーカー遺伝子の探索,日本生化学会大会(Web)[online],2017年11月15日,Vol. 90th,2PT26-10(3P-1145), Retrieved from the Internet,URL,https://www.aeplan.co.jp/conbio2017/
RIDLON J. M. et al.,Taurocholic acid metabolism by gut microbes and colon cancer,Gut Microbes,2016年 3月22日,Vol. 7, No. 3,p.201-215

Kenichi Nomura
Setuko Mayama

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