医薬組成物粒子とそれを含む口腔内崩壊製剤、医薬組成物粒子の製造方法

Japanese Patent JP6905972

B2

Provided are pharmaceutical composition particles which are capable of achieving both of masking of an unpalatable taste and improvement in dissolution properties; an orally disintegrating tablet including the pharmaceutical composition particles; and a method for manufacturing the pharmaceutical composition particles. Each of the pharmaceutical composition particles includes: a drug-containing core particle; an intermediate layer containing a gelling swelling substance and coating an outside of the core particle; and an outermost layer containing a water-insoluble substance and coating an outside of the intermediate layer. In addition, the method for manufacturing the pharmaceutical composition particles includes: a pulverization step of pulverizing the gelling swelling substance so as to have an average particle diameter of 15 µm or less; a suspension step of obtaining a suspension by suspending the gelling swelling substance pulverized at the pulverization step in an organic solvent; an intermediate layer formation step of forming an intermediate layer on an outside of a core particle by spraying the suspension obtained at the suspension step onto the core particle containing a drug; and an outer layer formation step of forming an outer layer by coating an outside of the intermediate layer with a water-insoluble substance.

Tomohiro Hayashida
Yohei
Shin Isami
Yoshio Nakano
Junji Yamazaki
Katsuhisa Inoue
Aizawa Atsushi

JP2018501704A

July 21, 2021

February 21, 2017

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NIPRO CORPORATION
Zensei Pharmaceutical Co., Ltd.

A61K47/38; A61K9/14; A61K9/20; A61K47/36

JP7072130B2
JP2008037863A
JP2009545560A
JP2011513204A
JP2001526213A
JP2007153884A

WO2007010930A1

Kazuo Akaoka
Akaoka Michio
Akiko Yoshioka

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