偏光に基づく蛍光核酸検出 - The General Hospital Corporation

Title:

偏光に基づく蛍光核酸検出

Document Type and Number:

Japanese Patent JP6920334

Kind Code:

B2

Abstract:

In an exemplary method, a sample is provided. The sample contains a polymerase molecule, a receptor molecule containing a fluorophore, and a detector molecule. The detector molecule is configured to, in the presence of a target nucleic acid, inhibit the polymerase molecule from cleaving the fluorophore. A level of fluorescence anisotropy from the sample is detected to determine the absence or presence of the target nucleic acid in the sample.

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Inventors:

Weiss Radar, Ralph
Lee, Hakuho
Park, Kiso
Juan, Chen-Han

Application Number:

JP2018550393A

Publication Date:

August 18, 2021

Filing Date:

March 27, 2017

Export Citation:

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Assignee:

The General Hospital Corporation

International Classes:

C12Q1/6816

Foreign References:

US20110117025
WO2014200767A1
US7141378
US20140046150
US20020055091

Other References:

Chem. Eur. J.,2015年,Vol.21, p.16359-16363
Chemical communications,2015年,Vol.51, p.9942-9945

Attorney, Agent or Firm:

Fukami patent office

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