Title:
センサデバイスのための電極のポリマーコーティング
Document Type and Number:
Japanese Patent JP6921217
Kind Code:
B2
Abstract:
An electrode comprising a functionalized surface exposable to a fluid sample. The functionalized surface comprises at least one polymer capable of mediating a salting-out effect and at least one detection agent that binds to an analyte comprised in the fluid sample, wherein the polymer and the detection agent are distributed on the surface of the electrode such that the detection agent is present in essentially equal amounts per surface area throughout the electrode surface and the polymer is arranged around the detection agent present in an amount allowing the reduction of the ionic strength of the fluid in proximity to the detection agent, and allowing for binding an analyte comprised in the fluid sample. A method for manufacturing a functionalized surface on an electrode, an analyte detector comprising the electrode, and the use of the analyte detector for determining at least one analyte in a fluid sample are also provided.
Inventors:
Thalassov, Alexei
Andoi, Nesha
Philippiac, Martin
Gutierrez-Sance, Oscar
Howstein, Natalie
Andoi, Nesha
Philippiac, Martin
Gutierrez-Sance, Oscar
Howstein, Natalie
Application Number:
JP2019546028A
Publication Date:
August 18, 2021
Filing Date:
February 21, 2018
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
G01N33/543; G01N27/414; G01N33/483
Domestic Patent References:
| JP2016038384A | ||||
| JP2009139113A |
Foreign References:
| WO2016161246A1 |
Other References:
GAO, Ning et al.,Specific detection of biomolecules in physiological solutions using graphene transistor biosensors,PANS,2016年,Vol.113, No.51, pp.14633-14638,URL,pans.org/content/pans/113/51/14633.full.pdf
MAGLIULO, Maria et al.,Label-free C-reactive protein electronic detection with an electrolyte-gated organic field-effect transistor-based immunosensor,Anal Bioanal Chem,2016年,DOI 10.1007/s00216-016-9502-3
YOSHIMOTO, Keitaro et al.,Direct Observation of Adsorption-Induced Inactivation of Antibody Fragments Surrounded by Mixed-PEG Layer on a Gold Surface,J.AM.CHEM.SOC.,2010年,Vol.132,pp.7982-7989
MAGLIULO, Maria et al.,Label-free C-reactive protein electronic detection with an electrolyte-gated organic field-effect transistor-based immunosensor,Anal Bioanal Chem,2016年,DOI 10.1007/s00216-016-9502-3
YOSHIMOTO, Keitaro et al.,Direct Observation of Adsorption-Induced Inactivation of Antibody Fragments Surrounded by Mixed-PEG Layer on a Gold Surface,J.AM.CHEM.SOC.,2010年,Vol.132,pp.7982-7989
Attorney, Agent or Firm:
Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi