Title:
量子センサーを使用したプロテオームアッセイ
Document Type and Number:
Japanese Patent JP6932861
Kind Code:
B2
Abstract:
Apparatus and methods for the detection of proteins in biological fluids such as urine using a label-free assay is described. Specific proteins are detected by their binding to highly specific capture reagents such as SOMAmers that are attached to the surface of a substrate. Changes to these capture reagents and their local environment upon protein binding modify the behavior of color centers (e.g., fluorescence, ionization state, spin state, etc.) embedded in the substrate beneath the bound capture reagents. These changes can be read out, for example, optically or electrically, for an individual color center or as an average response of many color centers.
Inventors:
Cleveland, Jason Paul
Holzer, calories
Vant-Halle, Barry Patrick John
Holzer, calories
Vant-Halle, Barry Patrick John
Application Number:
JP2020571335A
Publication Date:
September 08, 2021
Filing Date:
March 08, 2019
Export Citation:
Assignee:
SomaLogic, Inc.
International Classes:
G01N21/64; G01N24/00; G01N33/53; G01N33/543
Domestic Patent References:
| JP2005512022A | ||||
| JP2010533499A | ||||
| JP2014095025A |
Foreign References:
| US20110062957 | ||||
| US9759719 |
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Akiyo Iwahori
Rena Miyoshi
Kaoru Takahashi
Nao Oda
Akiyo Iwahori
Rena Miyoshi
Kaoru Takahashi