Title:
ＨＭＧＢ１に対する抗体、及びそれを含有するアルツハイマー病を治療又は予防するための組成物
Document Type and Number:
Japanese Patent JP6942358
Kind Code:
B2
Abstract:
An anti-HMGB1 antibody comprising a light chain variable region comprising complementarity-determining regions or the like including amino acid sequences of SEQ ID NOs: 4 to 6, and a heavy chain variable region comprising complementarity-determining regions or the like including amino acid sequences of SEQ ID NOs: 10 to 12, or an anti-HMGB1 antibody comprising a light chain variable region or the like comprising an amino acid sequence of SEQ ID NO: 3, and a heavy chain variable region comprising an amino acid sequence or the like of SEQ ID NO: 9, and a composition for treating or preventing Alzheimer's disease, comprising the same as an active ingredient.
Inventors:
Hitoshi Okazawa
Kajikawa Masuki
Kajikawa Masuki
Application Number:
JP2018533500A
Publication Date:
September 29, 2021
Filing Date:
August 08, 2017
Export Citation:
Assignee:
Tokyo Medical And Dental University, Medical Hospital
International Classes:
C12N15/13; A61K39/395; A61P25/28; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N5/20; C12N15/63
Domestic Patent References:
| JP2004107260A | ||||
| JP2008520552A | ||||
| JP2007320919A |
Other References:
TAKATA, K. et al.,Role of high mobility group protein-1(HMG1) in amyloid-β homeostasis,Biochemical and Biophysical Research Communications,2003年,301(3),pp.699-703
Attorney, Agent or Firm:
Patent Business Corporation St. Crest International Patent Office