Title:
エクソン５０のスキッピングを誘導するアンチセンス核酸
Document Type and Number:
Japanese Patent JP7201192
Kind Code:
B2
Abstract:
The present specification provides a drug that causes highly-efficient skipping of exon 50 in the human dystrophin gene. The present specification provides an antisense oligomer which induces skipping of exon 50 in the human dystrophin gene.
Inventors:
Yukiko Shioya
Yuta Sunadoi
Reiko Waki
Whip horse Somoe
Shinichi Takeda
Yoshitsugu Aoki
Yuta Sunadoi
Reiko Waki
Whip horse Somoe
Shinichi Takeda
Yoshitsugu Aoki
Application Number:
JP2022097020A
Publication Date:
January 10, 2023
Filing Date:
June 16, 2022
Export Citation:
Assignee:
NIPPON SHINYAKU CO.,LTD.
National Research and Development Agency National Center for Neurology and Psychiatry
National Research and Development Agency National Center for Neurology and Psychiatry
International Classes:
C12N15/113; A61K31/7088; A61K31/712; A61K48/00; A61P21/00
Domestic Patent References:
| JP2012506703A | ||||
| JP2013100190A1 |
Foreign References:
| US20190330626 |
Other References:
WU, B. et al.,Targeted skipping of human dystrophin exons in transgenic mouse model systemically for antisense drug development,PLoS One,2011年,Vol. 6(5):e19906,pp. 1-11
Attorney, Agent or Firm:
Hiroshi Kobayashi
Maruyama Tomohiro
Maruyama Tomohiro