Title:
単一粒子自動ラマン捕捉分析
Document Type and Number:
Japanese Patent JP7340547
Kind Code:
B2
Abstract:
An automated method of particle analysis is performed using an electromagnetic radiation source for generating a beam of electromagnetic radiation, a focusing element for directing the beam to a particle capture zone, a detector configured to detect a signal response from the particle capture zone and a control system. An electromagnetic radiation beam is focused onto a particle-conveying medium to define the particle capture zone for capturing a candidate particle within the beam. A first data acquisition procedure is performed to test for particle capture. If particle capture is not detected, the first data acquisition procedure is repeated. If a particle capture is detected within the beam, a second data acquisition procedure is performed to capture particle data using at least one analysis modality, following which the optical beam intensity is reduced to a sub-capture level to release the particle from the particle capture zone. The steps are repeated for successive particles in the particle-conveying medium.
Inventors:
Stevens, Molly
Pendels, Jelle
Pence, Isaac
Pendels, Jelle
Pence, Isaac
Application Number:
JP2020570740A
Publication Date:
September 07, 2023
Filing Date:
June 18, 2019
Export Citation:
Assignee:
Imperial College Innovations Limited
International Classes:
G01N15/02; G01N21/64; G01N21/65
Foreign References:
| US20140004559 | ||||
| EP2930496A1 | ||||
| US20160260513 | ||||
| US7515269 | ||||
| WO2017144886A1 |
Other References:
Daniel P. Cherney, Travis E. Bridges, and Joel M. Harris,Optical Trapping of Unilamellar Phospholipid Vesicles: Investigation of the Effect of Optical Forces on the Lipd Membrane Shape by Confocal-Raman Microscopy,Analytical Chemistry,Analytical Chemistry,2004年09月01日,Vol.76、No.17,4920-4928
JellePenders, Isaac J. Pence, et al,Single Particle Automated Raman Trapping Analysis,Nature Communications,Nature Communications,2018年10月15日,Vol.9、Nr:1
JellePenders, Isaac J. Pence, et al,Single Particle Automated Raman Trapping Analysis,Nature Communications,Nature Communications,2018年10月15日,Vol.9、Nr:1
Attorney, Agent or Firm:
Hiroshi Arafune