Title:
ピリドン誘導体と、その組成物、並びにそれらが抗ウイルス薬物としての応用
Document Type and Number:
Japanese Patent JP7352297
Kind Code:
B2
Abstract:
The present disclosure belongs to the field of medicinal chemistry, and relates to a novel pyridone derivative represented by Formula (I) or a stereoisomer, a pharmaceutically acceptable salt, a solvate or a crystal thereof, and use thereof in the preparation of a drug for preventing or treating diseases such as influenza type A viral infection and/or influenza type B viral infection, particularly use thereof as a PA subunit cap-dependent endonuclease inhibitor for preventing or treating diseases such as influenza type A viral infection and/or influenza type B viral infection. The compounds of the present disclosure have significant activity in inhibiting influenza endonuclease and influenza DNA, can be used either alone or in combination with a neuraminidase inhibitor, a nucleoside drug, a PB2 inhibitor, a PB1 inhibitor, an M2 inhibitor or other anti-influenza drugs, significantly shorten the time of influenza infection and reduces mortality, and have excellent clinical application prospects.
Inventors:
Chen Li
Shao Qing
Xue Xiaoken
Lee Hyomun
Shao Qing
Xue Xiaoken
Lee Hyomun
Application Number:
JP2020560532A
Publication Date:
September 28, 2023
Filing Date:
January 16, 2019
Export Citation:
Assignee:
Jiangxi Caishi Pharmaceutical Technology Co., Limited
International Classes:
C07D471/04; A61K31/53; A61K31/5383; A61K31/5386; A61K31/675; A61K45/00; A61P31/12; A61P31/16; A61P43/00; C07D471/14; C07D471/22; C07D491/20; C07D498/14; C07D498/22; C07F9/6561
Domestic Patent References:
| JP2017137291A |
Foreign References:
| WO2017104691A1 | ||||
| WO2012039414A1 | ||||
| WO2016175224A1 | ||||
| WO2010147068A1 |
Attorney, Agent or Firm:
Yuji Hayakawa
Keisuke Murasame
Hiroshi Taoka
Keisuke Murasame
Hiroshi Taoka