Title:
呼吸器合胞体ウイルスに対する予防のための環状ペプチド
Document Type and Number:
Japanese Patent JP7356911
Kind Code:
B2
Abstract:
The present invention relates to a cyclic peptide, a conjugate comprising said cyclic peptide and a lipopeptide building block, a bundle of said conjugates, a synthetic virus-like particle comprising at least one bundle of conjugates and pharmaceutical compositions comprising the same. The present invention further relates to said cyclic peptide, said conjugate said bundle of conjugates, said synthetic virus-like particle and said pharmaceutical compositions for use as a medicament, preferably for use in a method for preventing of an infectious disease or reducing the risk of an infectious disease, more preferably for use in a method for preventing or reducing the risk of an infectious disease associated with or caused by a respiratory syncytial virus.In particular, the present invention relates to a cyclic peptide, wherein said cyclic peptide comprises an amino acid sequence (I), wherein said amino acid sequence (I) comprises the following amino acid sequence:whereinX1, X2, X3, X5, X6, X7, X9, X10, X11, X22, X23, X24, X26, X27, X28 and X29 are independently of each other an amino acid; C4, C8, C21 and C25 are independently of each other cysteine; P12 is proline; 113 is isoleucine; T14 is threonine; N15 is asparagine; D16 is aspartic acid; Q17 is glutamine; K18 and K19 are independently of each other lysine; L20 is leucine; and X30 is an amino acid or a deletion,wherein said cysteines C4 and C25 form a first disulfide bond and said cysteines C8 and C21 form a second disulfide bond.
Inventors:
Gasparian, Arin
Zuniga, Armando
Marlelo Noders, Annie Breeze
Lasek, Oliver
Robinson, John A.
Mohr, Kerstin
Zuniga, Armando
Marlelo Noders, Annie Breeze
Lasek, Oliver
Robinson, John A.
Mohr, Kerstin
Application Number:
JP2019568204A
Publication Date:
October 05, 2023
Filing Date:
June 13, 2018
Export Citation:
Assignee:
Virometics Arge
Univel Zite Zurich
Univel Zite Zurich
International Classes:
C07K14/135; A61K39/155; A61P11/00; A61P31/14; A61P37/04
Domestic Patent References:
| JP2016517440A | ||||
| JP2016519658A | ||||
| JP2014519819A | ||||
| JP2013506654A | ||||
| JP2010512308A | ||||
| JP2008513540A |
Foreign References:
| WO2001089562A1 |
Other References:
J. Mol. Biol., 2011, Vol.409, No.5, pp.853-866
ChemBioChem, 2011, Vol.12, pp.100-109
ChemBioChem, 2011, Vol.12, pp.2829-2836
Angew. Chem. Int. Ed., 2007, Vol.46, pp.9015-9018
J. Gen. Virol., 1993, Vol.74, pp.2567-2577
ChemBioChem, 2011, Vol.12, pp.100-109
ChemBioChem, 2011, Vol.12, pp.2829-2836
Angew. Chem. Int. Ed., 2007, Vol.46, pp.9015-9018
J. Gen. Virol., 1993, Vol.74, pp.2567-2577
Attorney, Agent or Firm:
Sonoda & Kobayashi Patent Attorneys Corporation