Title:
ベンゾチアゾイミダゾリル化合物を含有する小胞体ストレス調節剤
Document Type and Number:
Japanese Patent JP7360106
Kind Code:
B2
Abstract:
A compound of general formula (1)[wherein:R1 and R2, which are the same or different, each represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower cycloalkyl group, a lower alkanoyl group, a halogen substituted lower alkyl group, a lower alkoxy group, a halogen substituted lower alkoxy group, a cyano group, a cross-linked methylenedioxy group, an ethylenedioxy group, a propylenedioxy group, a lower alkylthio group, a lower alkylsulfonyl group, a carboxyl group, a lower alkoxycarbonyl group, a lower alkylamide group, a lower alkylamino alkylene amide group, an amino group, an alkylamino group, a hydroxy group, a functional group represented by general formula (2), or a functional group represented by general formula (3)—CONH(CH2)p—R3 (2)[wherein R3 represents a di-lower alkylamino group, a morpholino group, a piperidino group, a 2-methyl-piperidino group, or a 2-oxo-pyrrolidinyl group; p represents an integer from 2 to 6];[wherein, R4 represents a lower alkyl group];m and n each represent an integer from 0 to 3;the term lower represents a carbon number of 1 to 6; andthe halogen atom represents a fluorine, chlorine or bromine atom] can inhibit endoplasmic reticulum stress to a greater extent as compared to known chemical chaperones. The compound thus can be used suitably as an agent for preventing, ameliorating or treating various diseases that are caused by endoplasmic reticulum stress.
Inventors:
Masakazu Oyadomari
Application Number:
JP2019562037A
Publication Date:
October 12, 2023
Filing Date:
December 25, 2018
Export Citation:
Assignee:
Endoplasmic reticulum stress laboratory Co., Ltd.
International Classes:
A61K31/429; A61P3/10; A61P9/10; A61P25/00; A61P25/16; A61P25/28; A61P43/00
Domestic Patent References:
| JP2016517442A | ||||
| JP2017193527A | ||||
| JP2001048786A | ||||
| JP2011529086A |
Foreign References:
| WO1998006724A1 |
Other References:
SAYERS CM. et al.,Identification and Characterization of a Potent Activator of p53-Independent Cellular Senescence via,MOLECULAR PHARMACOLOGY,2013年,Vol.83,p.594-604,Abstract,Fig.2A,2B、597ページ「E235 Activates the ISR in Transformed Cells」、600-601ペー
Attorney, Agent or Firm:
Hiroko Tada
Naomi Jinno
Tetsushi Kamidai
Naomi Jinno
Tetsushi Kamidai