Title:
抗生物質耐性ブレーカー
Document Type and Number:
Japanese Patent JP7454175
Kind Code:
B2
Abstract:
The invention relates to antibiotic compounds of formula (A1) and pharmaceutically acceptable salts, solvates, tautomers and combinations thereof, wherein X and L are optional linkers and one of RA or R1 comprises Ar1, wherein Ar1 is an antibiotic resistance breaker moiety which comprises an optionally substituted C6-10 aryl, C7-13 aralkyl, C5-10 heteroaryl, C6-13 heteroaralkyl, C5-10 heterocyclyl, C6-13 heterocyclalkyl, C3-10 carbocyclyl, C4-13 carbocyclalkyl, —C(═NR′)—NR′R″ or —CH2—CH═CH2 group; wherein after administration of the compound to a bacterial infection this moiety reduces or prevents efflux. The invention also discloses pharmaceutical compositions comprising compounds of formula (A1) and the use of such compounds as medicaments, in particular, to treat bacterial infections, such as drug-resistant bacterial infections.
Inventors:
Rahman Konda Kaer Mirazur
Jamshidhi Shirin
rose mark benjamin
Nahar Qazi
Sutton John Mark
hind charlotte
Jamshidhi Shirin
rose mark benjamin
Nahar Qazi
Sutton John Mark
hind charlotte
Application Number:
JP2019565892A
Publication Date:
March 22, 2024
Filing Date:
May 30, 2018
Export Citation:
Assignee:
KINGS COLLEGE LONDON
International Classes:
C07D498/06; A61K31/5383; A61K45/00; A61P11/00; A61P13/02; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P27/16; A61P31/04; A61P43/00
Domestic Patent References:
| JP6507149A |
Foreign References:
| WO2003078439A1 | ||||
| US5221676 | ||||
| US20030130302 | ||||
| KR1020160044768A |
Other References:
The Journal of Antibiotics,2016年,Vol. 69,pp. 415-421
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Yasunori Matsuhashi
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Hiroyuki Tomita
Seiji Ozawa
Yusaku Tokai
Yasunori Matsuhashi
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Hiroyuki Tomita