Title:
選択的アンドロゲン受容体分解剤（ＳＡＲＤ）リガンドおよびその使用方法
Document Type and Number:
Japanese Patent JP7456942
Kind Code:
B2
Abstract:
This invention is directed to selective androgen receptor degrader (SARD) compounds including heterocyclic rings and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
Inventors:
Narayanan, Ramesh
Miller, Duane, Dee.
Ponusami, Tamarai
Wang, Dong-Jin
F, spear
Miller, Duane, Dee.
Ponusami, Tamarai
Wang, Dong-Jin
F, spear
Application Number:
JP2020564332A
Publication Date:
March 27, 2024
Filing Date:
May 16, 2019
Export Citation:
Assignee:
Oncturnal Therapeutics, Inc.
University of Tennessee Research Foundation
University of Tennessee Research Foundation
International Classes:
A61K31/415; A61K8/49; A61K9/06; A61K9/08; A61K9/107; A61K9/127; A61K9/20; A61P5/24; A61P9/00; A61P13/08; A61P15/00; A61P15/14; A61P17/00; A61P17/10; A61P17/14; A61P21/02; A61P35/00; A61P35/04; A61P43/00; A61Q5/02; A61Q19/00; A61Q19/10; C07D231/16
Domestic Patent References:
| JP2013544768A |
Foreign References:
| WO2017214634A1 | ||||
| WO2016172358A1 |
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito