Document Type and Number:
Japanese Patent JPH0115485
Kind Code:
B2
Abstract:
Penicillins of formula (I), their salts and esters are new. In (I), Z is O or S. (I) are antibiotics with esp. high activity against Pseudomonas aeruginosa; e.g., (I; Z = O) gives MIC values of 0.5-8 mu g/ml against a large no. of Ps. aeruginosa strains, compared with >= 32 mu g/ml for carbenicillin. Combinations of (I) and amikacin, i.e. L-(-)-alpha-amino-alpha-hydroxybutynyl kanamycin A, in a ratio of 1:2-100 exhibit a synergistic effect in this respect. In an example, (I; Z = O) is prepd. from 1,2,4-triazine-3,5-dione-6-carboxylic acid azide and D(-)-6-(alpha-amino-4-hydroxyphenylacetamido)penicillanic acid.
Inventors:
SUTEFUIN RICHAADO BEEKAA
CHAARESU TORUUMAN HOORUDOREEJI
CHAARESU TORUUMAN HOORUDOREEJI
Application Number:
JP11911577A
Publication Date:
March 17, 1989
Filing Date:
October 05, 1977
Export Citation:
Assignee:
BRISTOL MYERS CO
International Classes:
A61K31/495; A61K31/715; A61P31/04; C07D253/075; C07D499/64; C07D499/68
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