Japanese Patent JPH0133115

B2

Novel steroids of the formula I' wherein R is selected from the group consisting of R1 and R2, R1 is selected from the group consisting of alkyl of 1 to 8 carbon atoms and alkenyl and alkynyl of 2 to 8 carbon atoms R2 is -(CH2)n-R3, n is an integer from 1 to 8 and R3 is selected from the group consisting of free or protected -OH, free or protected -NH2, monoalkyl and dialkylamino with 1 to 6 carbon atoms, a free, esterified or salified -COOH and halogen X and Y together form or X is OH and Y is -CH2-CH2-COOM, M is selected from the group consisting of hydrogen, an alkali metal and -NH4, Ra is selected from the group consisting of hydrogen and methyl, the dotted line in the I(2)-position indicates the optional presence of a double bond and the wavy line indicates that R may be in the alpha - or beta -position, with the proviso that R is not R1 or R2 when n is 1 and R3 is halogen, when the 1(2) bond is a simple bond and when Ra is -CH3, R3 is not a free carboxyl when Y is -CH2-CH2-COOM in which M is an alkali metal or -NH4 and R3 is not a salified carboxyl when Y is -CH2-CH2-COOH having aldosterone antagonistic properties and increases aqueous sodium diuresis while conserving organic potassium without secondary hormonal effects and their preparation.

RYUSHIAN NEDORETSUKU
BESUPERUTO TORERI
DANIERU FUIRIBEERU

JP20728481A

July 11, 1989

December 23, 1981

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ROUSSEL UCLAF

C07J5/00; A61K31/565; A61K31/57; A61K31/58; A61K31/585; A61P7/10; A61P9/00; A61P9/12; C07J1/00; C07J21/00; C07J41/00; C07J51/00

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