Document Type and Number:
Japanese Patent JPH0141626
Kind Code:
B2
Abstract:
Amrinone intermediates are prepared by reacting 4-picoline with at least three mole equivalents of phosgene per mole of 4-picoline and excess dimethylformamide to produce N-[3-dimethylamino-2-(4-pyridinyl)-2-propenylidene]-N-methylmethaniminium chloride hydrochloride, then reacting the latter with Q-CH2CONH2 and at least three mole equivalents of base in anhydrous medium and then neutralizing the reaction mixture to produce 5-Q-[3,4'-bipyridin]-6(1H)-one, where Q is cyano or carbamyl. Other aspects of the invention are the separate steps of preparing said iminium salt and then converting it to said 5-Q-[3,4'-bipyridin]-6(1H)-one, and also cardiotonic composition and method for increasing cardiac contractility using said iminium salt or pharmaceutically-acceptable acid-addition salt thereof as the active cardiotonic.
Inventors:
KAARU ORAFU JEROTSUTO
CHESUTAA JOSEFU OPARUKA JUNIAA
CHESUTAA JOSEFU OPARUKA JUNIAA
Application Number:
JP2759981A
Publication Date:
September 06, 1989
Filing Date:
February 26, 1981
Export Citation:
Assignee:
STERLING DRUG INC
International Classes:
A61K31/44; A61K31/4409; A61P9/04; C07D213/53; C07D213/82; C07D213/84; C07D213/85
Next Patent: JPH0141627