Document Type and Number:
Japanese Patent JPH0246577
Kind Code:
B2
Abstract:
The invention relates to a novel process and novel intermediates useful in the preparation of sympathomimetic amines. The pharmacologically useful final products, which are acyl derivatives of mono- and dihydroxy aromatic amines (e.g., catechol amines) can be prepared in optically active or racemic form by reacting the corresponding mono- or dihydroxy aromatic amine with a reagent capable of forming the N-tert-butoxycarbonyl derivative thereof; reacting the novel intermediate thus obtained with an acyloxymethyl chloride to afford the corresponding novel mono- or diacylated N-protected aromatic amine; and removing the N-protecting group therefrom.
Inventors:
ZUPAN JAKOBU EE
Application Number:
JP50241480A
Publication Date:
October 16, 1990
Filing Date:
September 24, 1980
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
C07C271/16; C07C67/00; C07C239/00; C07C271/06; C07C309/63
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