Document Type and Number:
Japanese Patent JPH0258266
Kind Code:
B2
Abstract:
The present invention relates to a novel process for the preparation of 7 beta -amino-3- or -2-cephem-3-ol-4-carboxylic acid compound of the formula IA or the formula IB in which R@ denotes hydrogen or an amino protective group R@, R@ represents hydrogen or an acyl group Ac, or R@ and R@ together denote a bivalent amino protective group, R<2> represents hydroxyl or a radical R@ which together with the carbonyl group -C(=O)-, forms a protected carboxyl group, and R<3> represents hydrogen, lower alkyl or optionally substituted alpha -phenyl-lower-alkyl, characterised in that, in a compound of the formula in which the double bond can be in the 2,3- or 3,4-position, the amino group -N(R@)(R@) is subjected to solvolysis to give the -OR3 group.
Inventors:
RABATO BAANZU UTSUDOWAADO
HANSU BITSUKERU
HANSU BITSUKERU
Application Number:
JP1830786A
Publication Date:
December 07, 1990
Filing Date:
January 31, 1986
Export Citation:
Assignee:
CIBA GEIGY
International Classes:
C07D205/08; A61K31/397; A61K31/545; A61K31/546; A61P31/04; C07D205/095; C07D417/12; C07D499/00; C07D501/08; C07D501/10; C07D501/59; C07D501/60