Document Type and Number:
Japanese Patent JPH0316356
Kind Code:
B2
Abstract:
PURPOSE:A 2-thioxopenam-3-carboxylic derivative is made to react with an alkylating reagent or hydroxy compound and an azo compound to produce the titled compound used as an antibacterial or synthetic intermediate thereof. CONSTITUTION:The reaction between a compound of formula 2 (R<7> is H, lower alkyl, lower alkoxy R<9> is carboxyl-protecting group) and another compound of formula 4 (R<2> is H, lower alkyl R<8> is amino-protecting group A is lower alkylene with a branched chain X is halogen) affords a compound of formula 3. Or the reaction between the compound of formula 2, a compound of formula 5 and the third compound of R<10>OOCN=NCOOR<10> (R<10> is alkyl) is conducted in the presence of triphenylphosphine to give the compound of formula 3. When necessary, the protecting groups are removed or the substituted groups are exchanged to produce the compound of formula 1 (R<1> is R<7>, lower hydroxyalkyl R<3> is H, R<8> R<4> is H, R<9>) and its salt.
Inventors:
MYADERA TETSUO
SUGIMURA MASAO
TANAKA TERUO
HASHIMOTO TOSHIHIKO
IINO KIMIO
SUGAWARA SHINICHI
SUGIMURA MASAO
TANAKA TERUO
HASHIMOTO TOSHIHIKO
IINO KIMIO
SUGAWARA SHINICHI
Application Number:
JP7612980A
Publication Date:
March 05, 1991
Filing Date:
June 06, 1980
Export Citation:
Assignee:
SANKYO CO
International Classes:
C07D499/897; A61K31/43; A61P31/04; C07D499/88; C07F7/18
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