Document Type and Number:
Japanese Patent JPH0316357
Kind Code:
B2
Abstract:
PURPOSE:The reaction of an azetidin-2-one derivative with a phosphorous triester or phosphorous acid triamide affords the titled compound that is important as a synthetic intermediate of penem-3-carboxylic acids, antibiotics. CONSTITUTION:The reaction between a compound of formula I [R<1> is H, alkyl, R<4>A (R<4> is hydroxyl, alkoxy, acyloxy; A is alkylidene that may be substituted with trifluoromethyl); R<2> is alkyl, alkenyl, aralkyl; R<3> is carboxyl-protecting group; X is O, S; Y is O, S] and a phosphorous triester or phosphorous acid triamide is conducted in a solvent such as methanol or propanol to give the compound of formula II. The phosphorous triester is expressed by (R<4>)3P (R<4> is alkoxy, dialkylamino) and the amount used is 2-20 equivalents per the compound of formula I.
Inventors:
OOKI EIJI
OIDA SADAO
YOSHIDA AKIRA
HAYASHI TERUO
SUGAWARA SHINICHI
OIDA SADAO
YOSHIDA AKIRA
HAYASHI TERUO
SUGAWARA SHINICHI
Application Number:
JP8498180A
Publication Date:
March 05, 1991
Filing Date:
June 23, 1980
Export Citation:
Assignee:
SANKYO CO
International Classes:
C07D499/897; A61K31/397; A61K31/43; A61P31/04; C07D205/08; C07D205/09; C07D499/00; C07D499/06; C07D499/88
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