Document Type and Number:
Japanese Patent JPH0331716
Kind Code:
B2
Abstract:
There is provided a process for preparing in high yields a 6-[D(-)- alpha-(4-C1-C4-alkyl-2,3-dioxo-1- piperazinocarbonylamino)- phenylacetamido]penicillanic acid, or pharmaceutically acceptable salt thereof, in which a 4-C1-C4-alkyl- 2,3-dioxo-1-piperazinocarbonyl halide is added under controlled pH conditions to a solution or suspension of ampicillin in a mixture of ethyl acetate and water in the presence of a base to form a reaction mixture, the resulting mixture is agitated until the reaction is completed, the reaction mixture is acidified, and the desired antibiotic is recovered as a crystalline product under controlled pH conditions and using controlled amounts of ethyl acetate as solvent.
Inventors:
DONARUDO SHII BUUPU
KARERU EFU BAANADEI
KARERU EFU BAANADEI
Application Number:
JP2617082A
Publication Date:
May 08, 1991
Filing Date:
February 22, 1982
Export Citation:
Assignee:
AMERICAN CYANAMID CO
International Classes:
A61K31/43; A61K31/495; A61P31/04; C07D499/00; C07D499/04; C07D499/08; C07D499/12; C07D499/64; C07D499/68
Next Patent: JPH0331717