Document Type and Number:
Japanese Patent JPH0339058
Kind Code:
B2
Abstract:
The invention relates to a method of preparing 1 alpha -hydroxyvitamin D or 1 alpha -hydroxy-previtamin D compounds by hydroxylating the 1 alpha -position of an adduct of a previtamin D compound with a suitable dienophile, in which adduct optionally present hydroxy group or hydroxy groups is or are protected, if desired, and after removal of the protecting group or groups, isolating the 1 alpha -hydroxyvitamin D or 1 alpha -hydroxy-previtamin D compound. The invention also relates to 1 alpha -hydroxy-previtamin D compounds. The invention further relates to an adduct of a previtamin D or tachysterol compound with a dienophile of the general formula in which A' and B' are equal and represent methoxy groups or ethoxy groups, or in which A' and B' together constitute a phenylimino or o-phenylene group.
Inventors:
MAURITSUTSU FUANDEUARE
RUKU YAA FUANMERE
PIERU JIII DO KURERUKU
SEBASUCHIANUSU YAA HARUKESU
UIRUHERUMUSU AARU EMU OBERUBIIKU
RUKU YAA FUANMERE
PIERU JIII DO KURERUKU
SEBASUCHIANUSU YAA HARUKESU
UIRUHERUMUSU AARU EMU OBERUBIIKU
Application Number:
JP12306582A
Publication Date:
June 12, 1991
Filing Date:
July 16, 1982
Export Citation:
Assignee:
DUPHAR INT RES
International Classes:
A61K31/59; A61K31/50; A61K31/502; A61P3/02; A61P3/14; C07C67/00; C07C401/00; C07D237/26; C07D487/04; C07F7/18
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