Title:
【発明の名称】ゴナドトロピンおよびTSHのスーパーアゴニストの製造方法並びに該製造方法で製造したスーパーアゴニスト
Document Type and Number:
Japanese Patent JPH03502525
Kind Code:
A
Abstract:
Methods are provided for producing super-agonist hormones, which hormones are those having the common alpha subunit of the gonadotropins, generally comprising the transformation of host cells with recombinant DNA comprising a first DNA sequence coding for an alpha subunit from an equine animal species and a second DNA sequence coding for a beta subunit from a non-equine species. The preffered hormone comprises an equine alpha subunit and a bovine, porcine or human beta subunit of LH, FSH, CG or TSH and exhibits a greatly increased activity.
Inventors:
Chapel, Scott Sea
Nugent, Noreen Pee
Nugent, Noreen Pee
Application Number:
JP50897189A
Publication Date:
June 13, 1991
Filing Date:
August 30, 1989
Export Citation:
Assignee:
Applied Research Systems ARS Holding NV
International Classes:
C07K1/20; C07K14/00; C07K14/575; C07K14/59; C07K19/00; C12N15/09; C12N5/10; C12N15/16; C12P21/00; C12R1/91; (IPC1-7): C07K15/12; C12N5/10; C12N15/16; C12N15/62; C12P21/00
Attorney, Agent or Firm:
Toda Chikio
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