Document Type and Number:
Japanese Patent JPH0354652
Kind Code:
B2
Abstract:
Pharmaceutically useful optically active alpha -arylalkanoic acids of the formula where Ar is aryl and R1 is alkyl or cycloalkyl or esters, ortho esters, or amides thereof are stereoselectively prepared by contacting a reagent of the formula Ar-MX, (Ar) 2M or ArM' where M is Cd, Cu(II), Mn(II), Mg or Zn, and M' is Cu(I) or Li, and X is halogen, with an optically active compound of the formula where Z is a leaving group and Y is halogen, acyloxy or where R' and R'' are alkyl, aryl or with N are a heterocyclic group, to form the optically active ketone of the formula which is ketalized and rearranged to said acid, ester, ortho ester or amide. Alternatively, said ketone is reduced to the corresponding alkanol, which is rearranged to the alpha -arylalkanal. The alkanal so produced is converted to said acid by conventional methods.
Application Number:
JP21676582A
Publication Date:
August 20, 1991
Filing Date:
December 10, 1982
Export Citation:
International Classes:
C07C41/60; C07B61/00; C07C41/00; C07C41/50; C07C43/295; C07C43/307; C07C43/313; C07C43/315; C07C43/32; C07C45/00; C07C45/45; C07C45/54; C07C45/68; C07C47/277; C07C49/76; C07C49/84; C07C51/00; C07C57/30; C07C57/40; C07C57/46; C07C59/64; C07C67/00; C07C67/343; C07C67/40; C07C67/42; C07C67/44; C07C67/475; C07C69/007; C07C69/025; C07C69/157; C07C69/527; C07C69/616; C07C69/712; C07C69/734; C07C69/767; C07C69/78; C07C231/00; C07C231/02; C07C233/11; C07C301/00; C07C303/30; C07C309/63; C07C309/66; C07C309/73; C07D309/22; C07D317/02; C07D317/06; C07D317/14; C07D317/18; C07D317/22; C07D317/24; C07D319/06; C07F3/02; C07F3/06; C07F7/08; C07F7/18; C07F13/00; C07C
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