Document Type and Number:
Japanese Patent JPH0354939
Kind Code:
B2
Abstract:
PROCESS FOR THE PREPARATION OF /2S,3S/-3-ACETOXY-5- -/N,N-DIMETHYLAMINOETHYL/-2-/4-METHOXYPHENYL/-2,3- -DIHYDRO-1,5-BENZOTHIAZEPIN-4/5H/-ONE A b s t r a c t The invention relates to a new process for the preparation of /2S,3S/-3-acetoxy-5-/N,N-dimethyl-aminoethyl/-2-/4-methoxyphenyl/-2,3-dihydro-1,5-benzo-thiazepin-4/5H/-one of the formula /I/ ![]()
(1) and acid addition salts thereof, by a/ alkylation and acetylation of /2S,3S/-3- -hydroxy-2-/4-methoxyphenyl/-2,3-dihydro-1,5-benzo-thiazepin-4/5H/-one of the formula /III/ ![]()
(111) in an optional order, or b/ alkylation of 3-acetoxy-2-/4-methoxyphenyl/- -2,3-dihydro-1,5-benzothiazepin-4/5H/-one of the formula /V/ ![]()
(V) and if desired, conversion of the compound of formula /I/ obtained into an acid addition salt thereof, w h i c h c o m p r i s e s carrying out the alkylation with 2-dimethylaminûethanol mesylate hydrochloride and/or carrying out the acetylation with isopropenyl acetate.
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Application Number:
JP26363086A
Publication Date:
August 21, 1991
Filing Date:
November 05, 1986
Export Citation:
International Classes:
A61K31/55; A61K31/554; A61P9/00; C07D281/10