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Document Type and Number:
Japanese Patent JPH0375559
Kind Code:
B2
Abstract:
Compounds having the structure: wherein B represents a purine, 7-deazapurine, or pyrimidine moiety covalently bonded to the C<1>-position of the sugar moiety, provided that when B is purine or 7-deazapurine, it is attached at the N<9>-position of the purine or 7-deazapurine and when B is pyrimidine, it is attached at the N<1>-position: wherein A represents a moiety consisting of at least three carbon atoms which is capable of forming a detectable complex with a polypeptide when the compound is incorporated into a double-stranded ribonucleic acid, deoxyribonucleic acid duplex, or DNA-RNA hybrid; wherein the dotted line represents a chemical linkage joining B and A, provided that if B is purine, the linkage is attached to the 8-position of the purine, if B is 7-deazapurine, the linkage is attached to the 7-position of the deazapurine, and if B is pyrimidine, the linkage is attached to the 5-position of the pyrimidine; and wherein each of x, y and z represents either directly, or when incorporated into oligo- and polynucleotides, provide probes which are widely useful. Applications include detection and localization of polynucleotide sequences in chromosomes, fixed cells, tissue sections, and cell extracts. Specific applications include chromosomal karyotyping, clinical diagnosis of nucleic acid-containing etiological agents, e.g. bacteria, viruses, or fungi, and diagnosis of genetic disorders.

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Inventors:
DEIBIDO SHII UOODO
PENINA AARU RANGAA
AREGUZANDAA EI UORUDOROTSUPU ZA SAADO
Application Number:
JP6461182A
Publication Date:
December 02, 1991
Filing Date:
April 16, 1982
Export Citation:
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Assignee:
UNIV YALE
International Classes:
G01N33/50; C07H19/06; C07H19/073; C07H19/10; C07H19/14; C07H19/16; C07H19/173; C07H19/20; C07H21/00; C07H21/02; C07H21/04; C07H23/00; C12N15/00; C12N15/09; C12P19/34; C12Q1/04; C12Q1/18; C12Q1/68; C12Q1/6804; C12Q1/6816; G01N33/53; G01N33/58; G01N33/68



 
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