Document Type and Number:
Japanese Patent JPH039104
Kind Code:
B2
Abstract:
5-Thiaprostagliandins E1 having the general formula (I): wherein R<1> represents a hydrogen atom, a C1-C10 alkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted C3-C10 cycloalkyl group, a substituted or unsubstituted phenyl (C1-C2) aklyl group, or one equivalent cation; R<2> and R<3>, which may be the same or different, represent a hydrogen atom, a tri(C1-C7) hydrocarbon silyl group, or a group forming an acetal linkage together with an oxygen atom of a hydroxyl group; R<4> represents a hydrogen atom, a methyl group, an ethyl group or a vinyl group: and R<5> represents a linear or branched C3-C8 alkyl group, a linear or branched C3-C8 alkenyl group, a linar or branched C3-C8 alkynyl group, a phenyl group which may be substituted, a phenoxy group which may be substituted, a C3-C0 cycloalkyl group which may be substituted, or a linear or branched C1-C5 aklyl group substituted with a C1-C6 alkoxy group, a phenyl group which may be substituted, a phenoxy group which may be substituted, or a C3-C10 cycloalkyl group which may be substituted. Such compounds are especially useful for the treatment and prevention of digestive organic diseases such as a duodenal ulcer or a gastric ulcer.
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Inventors:
MANABE KENJI
OKAMURA NORIAKI
KUROZUMI SEIJI
OKAMURA NORIAKI
KUROZUMI SEIJI
Application Number:
JP7451985A
Publication Date:
February 07, 1991
Filing Date:
April 10, 1985
Export Citation:
Assignee:
TEIJIN LTD
International Classes:
A61K31/557; A61K31/5575; A61P1/04; A61P43/00; C07C67/00; C07C401/00; C07C405/00