Document Type and Number:
Japanese Patent JPH0415778
Kind Code:
B2
Abstract:
A phenol derivative of the formula NU-A-X-R1 wherein NU is a defined bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxyindanyl, hydroxyphenyl-hydroxybenzothienyl or di-hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages, wherein R1 is hydrogen, or alkyl, alkenyl, cycloalkyl, halogenoalkyl, aryl or arylalkyl, or R1 is joined to R2, and wherein X is -CONR2-, -CSNR2-, -NR12CO-, -NR12CS-, -NR12CONR2-, -SO2NR2- or -CO-, or, when R1 is not hydrogen, is -NR12COO-, -S-, -SO- or -SO2-, wherein R2 is hydrogen or alkyl, or R1 and R2 together form alkylene; wherein R12 is hydrogen or alkyl, and wherein R22 is hydrogen, cyano or nitro; or a salt thereof when appropriate. The compounds possess antioestrogenic activity and may be used for the treatment of hormone-dependent breast tumours or of anovulatory infertility.
Inventors:
GURAHAMU CHAARUSU KUROORII
FUIRITSUPU NIIRU EDOWAAZU
JOOJI BEASUFUOODO HIRU
UIRIAMU ROBAATO PIRUGURIMU
BURAIAN SUTEIIRU TAITO
DEREKU UIRIAMU YANGU
FUIRITSUPU NIIRU EDOWAAZU
JOOJI BEASUFUOODO HIRU
UIRIAMU ROBAATO PIRUGURIMU
BURAIAN SUTEIIRU TAITO
DEREKU UIRIAMU YANGU
Application Number:
JP8764884A
Publication Date:
March 19, 1992
Filing Date:
April 28, 1984
Export Citation:
Assignee:
ICI PLC
International Classes:
A61K31/165; A61K31/10; A61K31/135; A61K31/19; A61K31/215; A61K31/22; A61K31/27; A61K31/38; A61K31/381; A61P13/02; A61P15/00; C07C43/225; C07C43/23; C07C45/30; C07C45/44; C07C45/46; C07C45/51; C07C45/60; C07C45/68; C07C49/755; C07C59/64; C07C59/72; C07C62/34; C07C67/00; C07C231/00; C07C231/02; C07C231/12; C07C233/12; C07C233/18; C07C235/34; C07C279/00; C07C301/00; C07C303/38; C07C311/00; C07C311/02; C07C311/16; C07C311/24; C07C311/26; C07C313/00; C07C315/04; C07C317/00; C07C317/04; C07C317/18; C07C317/24; C07C317/28; C07C317/44; C07C319/20; C07C323/11; C07C323/16; C07C323/41; C07C323/42; C07C323/44; C07C323/51; C07C323/60; C07C325/00; C07C327/40; C07C327/42; C07C327/46; C07C327/50; C07D333/60; C07D333/64; C07F7/18; C07F9/655