- Patent JPH0419229

Document Type and Number:

Japanese Patent JPH0419229

Kind Code:

B2

Abstract:

New cephalosporins are of formula (I) In the formula R and R1 are both H or both hydrolysable or hydrogenolysable gps. or R1 can also be opt. substd. 1-4C alkyl, A is H or an equiv. of an alkali(ne earth) metal or an amine. (I) have antibacterial activity against Gram-positive and -negative bacteria, esp. penicillin-resistant Staphylococci, E.coli, Klebsiella, Salmonella and Proteus spp. A typical cpd. is 3-acetoxymethyl-7-(2-(2-tritylamino-4-thiazolyl)-2-tritylhydroxyi- mino-acetamido)-3-cephem-4-carboxylic acid. In an example, this is prepd. starting from ethyl gamma-chloro-alpha-oximinoacetyl-acetate.

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Inventors:

RUNE EEMU
ANDORE RYUTSUTSU

Application Number:

JP13007787A

Publication Date:

March 30, 1992

Filing Date:

May 28, 1987

Export Citation:

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Assignee:

ROUSSEL UCLAF

International Classes:

C07D277/20; A61K31/545; A61K31/546; A61P31/04; C07C67/00; C07C239/00; C07C251/32; C07D277/38; C07D277/40; C07D277/42; C07D417/12; C07D501/20; C07D501/34; C09D175/04

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