Document Type and Number:
Japanese Patent JPH0424356
Kind Code:
B2
Abstract:
New technetium [99m] (1) complexes can be used in imaging compositions for example in myocardial imaging. The complexes have one of the following formulae:
<99m>Tc (I) [P(R<1>, R<2>, R<3>)]6<+>A<-> 1
wherein R<1>, R<2> and R<3> are independently selected from the group consisting of lower alkyl, lower alkoxy, and lower alkory-substituted lower alkyl, provided each phosphorus is bonded through at least one oxygen to a carbon; and A<-> is a non-deleterious, chemically suitable, pharmaceutically acceptable anion;
<99m>Tc (I) [P(X. R<1>)]6<+>A<-> 2
wherein X is a bridging substituent selected from the group consisting of lower alkylenedioxy, and lower oxyalkyl; R<1> has the same meaning as set forth above, provided each phosphorus is bonded through at least one oxygen to a carbon, and A<-> has the same meaning as set forth above;
<99m>Tc (I) [PY]6<+>A<-> 3
wherein Y is a trivalent bridging substituent selected from the group consisting of lower tri(oxyalkylene)alkane, lower oxydialkyl, and lower dioxyalkyl, provided each phosphorus is bonded through at least one oxygen to a carbon; and A<-> has the same meaning as set forth above;
<99m>Tc (I) [R<4>, R<5>-P-R<6>-P-R<7>, R<8>]3<+>A<-> 4
wherein R<4>, R<5>, R<7> and R<8> are independently selected from the group consisting of, lower alkyl, lower alkoxy, and lower alkoxy-substituted lower alkyl; R<6> is a linking substituent selected from the group consisting of lower alkylene, oxygen, lower alkylenedioxy and lower oxyalkylene, provided each phosphorus is bonded through at least one oxygen to a carbon; and A<-> has the same meaning as set forth above; and
<99m>Tc (I) [X-P-R<6>-P-X]3<+>A<-> 5
wherein X, R<6> and A<-> have the same meaning as set forth above and provided each phosphorus is bonded through at least one oxygen to a carbon.
Inventors:
RICHAADO TEII DEIIN
FUREDERITSUKU DABURYUU MIRAA
DENISU DABURYUU UESUTAA
FUREDERITSUKU DABURYUU MIRAA
DENISU DABURYUU UESUTAA
Application Number:
JP17951884A
Publication Date:
April 24, 1992
Filing Date:
August 30, 1984
Export Citation:
Assignee:
MALLINCKRODT INC
International Classes:
C07F13/00; A61K49/04; A61K51/04; C07F9/142; C07F9/48; C07F9/6574
Next Patent: JPH0424357