Document Type and Number:
Japanese Patent JPH0446281
Kind Code:
B2
Abstract:
Complexable heterogeneous oligosaccharides and pure alpha-hydosanes, namely not contaminated from other macromolecules (mucopolysaccharides, proteins, nucleic acids, etc.) of a defined molecular weight, are produced starting from a mixture of mucopolysaccharides obtained starting from bovine or swine mucosa through a process comprising a precipitation with organic solvents, a further purification by means of specific enzymes and chromatographic separation by gel filtration. Heterogeneous oligosaccharides are obtained which can be complexed with metals, being thus able to promote the pharmacological effect of the metal thanks to the greater permeability towards the complexes of the membrane of the cells of the absorbing mucosa and of the cells of the target tissue. There are also obtained pure alpha-hydosanes having a well defined molecular weight range capable of providing several pharmacological activities, more particularly an activating effect of the anti-thrombine III, a potentiating effect of the tissutal activator and a fibrine depolymerizing effect have been found for some of them, whereas for some others an effect on the factor Xa/PTT ratio has been revealed and lastly for still others a lipasemic and anti-coagulating activity has been found.
Inventors:
MATSUSHIMO BARUDATSUCHI
UGO BARUDATSUCHI
UGO BARUDATSUCHI
Application Number:
JP14452484A
Publication Date:
July 29, 1992
Filing Date:
July 13, 1984
Export Citation:
Assignee:
RABO* BARUDATSUCHI SPA
International Classes:
C07H11/00; A61K31/70; A61K31/715; A61P3/06; A61P7/02; A61P7/06; C08B37/00; C08B37/10; A61K; C07D
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