Japanese Patent JPH0514558

B2

A method for producing optically active glycol derivatives by biochemical resolution which comprises contacting a racemic ester of the general formula 1(wherein R, is an aliphatic hydrocarbon group of 1 to 16 atoms, R₂ is an aliphatic hydrocarbon group of 1 to 8 carbon atoms, and R₃ is an aromatic hydrocarbon group) with a microorganism- or animal organ-derived enzyme having stereoselective esterase activity to asymmetrically hydrolyze said racemic ester of general formula 1 to produce an optically active alcohol of general formula 2^*(wherein R₁ and R₃ have the same meanings as defined above) and an unreacted ester of the general formula 1^*(wherein R,, R₂ and R₃ have the same meanings as defined hereinbefore), separating the optically active compounds from each other, hydrolyzing said ester of general formula 1^* to give an optically active glycol derivative which is antipodal to the alcohol of general formula 2^* and, then, isolating the same optically active glycol derivative. The invention provides a method for producing optically active glycol derivatives, which is expedient, does not require costly reagents and is suited to commercial scale production.

HAMAGUCHI SHIGEKI
OOHASHI TAKEHISA
WATANABE KYOSHI

JP6977085A

February 25, 1993

April 01, 1985

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KANEGAFUCHI CHEMICAL IND

C07B31/00; C07C67/00; C07C301/00; C07C303/22; C07C309/72; C12P11/00; C12P41/00; C12R1/01; C12R1/38; C12R1/66; C12R1/785; C12R1/845

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