Title:
【発明の名称】蛋白質のテクネチウム/レニウム標識方法
Document Type and Number:
Japanese Patent JPH05500800
Kind Code:
A
Abstract:
A method for radiolabeling a protein with a radioisotope of technetium or rhenium comprises the steps of contacting a solution of a protein containing a plurality of adjacent free sulfhydryl groups, or in particular cases, intact protein containing at least one disulfide group, with stannous ions, and then with radiopertechnetate or radioperrhenate, the amount of stannous ion being sufficient to substantially completely reduce the radiopertechnetate or radioperrhenate, and recovering radiolabeled protein.
More Like This:
Inventors:
Griffith, Garry, Elle.
Application Number:
JP50983790A
Publication Date:
February 18, 1993
Filing Date:
June 11, 1990
Export Citation:
Assignee:
Immunomedics Incorporated
International Classes:
A61K51/00; A61K51/08; A61K39/395; A61K51/10; A61P31/00; A61P35/00; C07B59/00; C07K1/13; C07K16/00; C12N9/00; G01N33/534; A61K; A61N; G01N; G01T; (IPC1-7): A61K49/02; A61K43/00; A61K39/395
Attorney, Agent or Firm:
Yoshio Kawaguchi (3 outside)