Title:
【発明の名称】障害を受けた組織における血管漏洩を抑制する抗炎症ペプチド及びその組織の治療方法
Document Type and Number:
Japanese Patent JPH05503103
Kind Code:
A
Abstract:
Relatively small, synthetic anti-inflammatory peptides are provided having the primary sequence TN-A1-A2-A3-A4-A5-A6-TC in which TN is an amino acid portion, A1 through A6 each is a synthetic or natural amino acid in the D- or L-configuration, and TC is a part of or comprises an amidated carboxyl terminal portion. Each of A1, A2 and A5 is a polar amino acid while each of A3, A4 and A6 is a nonpolar amino acid. These relatively small, synthetic peptides inhibit vascular leakage and are usefully administered to mammals for applications such as in the treatment of edema in connection with brain, skin, mucosal and musculature injuries.
Inventors:
Way Edward Tee.
Application Number:
JP50298691A
Publication Date:
May 27, 1993
Filing Date:
January 04, 1991
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
A61P29/00; C07K7/06; C07K14/575; A61K38/00; (IPC1-7): A61K37/02; C07K7/06; C07K99/00
Attorney, Agent or Firm:
Shoichi Hase (1 person outside)