Title:
【発明の名称】一価の抗体フラグメントの改良された放射性標識方法
Document Type and Number:
Japanese Patent JPH05506218
Kind Code:
A
Abstract:
A method for radiolabeling a monovalent Fab or Fab' antibody fragment which comprises the steps of cleaving a divalent F(ab)2 or F(ab')2 antibody fragment using sulfite or meta-bisulfite ions to produce a monovalent fragment having a free sulfhydryl group, and contacting the monovalent fragment with a cation of a metallic radionuclide which binds to sulfhydryl groups, without removing excess sulfite or metabisulfite.
Inventors:
Jiang, Xian-sin
The Jons, Anastasia Shya Renchin
The Jons, Anastasia Shya Renchin
Application Number:
JP50714591A
Publication Date:
September 16, 1993
Filing Date:
March 05, 1991
Export Citation:
Assignee:
Immunome Dex, Inc.
International Classes:
A61K51/00; A61K51/10; C07K16/06; G01N33/534; G01N33/68; A61K38/00; (IPC1-7): A61K49/02; G01N33/534
Domestic Patent References:
| JPS62230800A | 1987-10-09 | |||
| JPS62265398A | 1987-11-18 |
Attorney, Agent or Firm:
Yoshio Kawaguchi (3 outside)