Title:
【発明の名称】リポソームへの成長ホルモン類の結合
Document Type and Number:
Japanese Patent JPH05506251
Kind Code:
A
Abstract:
Crosslinking reagents glutaraldehyde and ethylene glycol diglycidyl ether have been used to bind epidermal growth factor ("EGF") to liposomal surfaces without utilizing the disulfide bridge linkage of EGF and, therefore, not adversely affecting the functionality of EGF. The crosslinking occurs through the amine residues offered by EGF and liposomes having phosphatidylethanolamine. The resulting EGF-modified liposomes offer potential as a microscopic drug delivery system.
Inventors:
Margarit, Rimona
Application Number:
JP50565992A
Publication Date:
September 16, 1993
Filing Date:
October 30, 1991
Export Citation:
Assignee:
Baxter, International, Inc.
International Classes:
A61K9/127; A61K38/22; (IPC1-7): A61K37/24; A61K9/127
Attorney, Agent or Firm:
Akaoka Mio