Title:
【発明の名称】フロルフェニコール、その類似体およびそのオキサゾリン中間体の製造方法
Document Type and Number:
Japanese Patent JPH05507289
Kind Code:
A
Abstract:
PCT No. PCT/US91/07608 Sec. 371 Date Apr. 22, 1993 Sec. 102(e) Date Apr. 22, 1993 PCT Filed Oct. 23, 1991.A process for preparing a compound of formula (IV): (IV) comprising a) contacting an oxazoline compound of formula (I): (I) wherein Z is as defined hereinbefore, with a reagent capable of causing an equilibrium between oxazoline compound (I) and an oxazoline compound of formula (II) described herein, and the reagent drives the equilibrium toward oxazoline compound (II) by preferential precipitation of oxazoline compound (II); b) contacting compound (II) with a fluorinating agent to give a fluorinated oxazoline compound of formula (III) described herein; and c) hydrolyzing the compound of formula (III) to formula (IV). In an alternative embodiment, the process is directed toward a process for preparing oxazoline (II) in a single step.
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Inventors:
Clark, John Yee
Schumacher, Doris Peas
U, guan-zon
Schumacher, Doris Peas
U, guan-zon
Application Number:
JP50071892A
Publication Date:
October 21, 1993
Filing Date:
October 23, 1991
Export Citation:
Assignee:
SCHERING CORPORATION
International Classes:
C07C231/10; C07C233/18; C07C315/04; C07C317/32; C07C317/40; C07C319/20; C07C321/28; C07D263/10; C07D263/14; (IPC1-7): C07C231/10; C07C233/18; C07C315/04; C07C317/32; C07C319/20; C07C321/28; C07D263/10; C07D263/14
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)