Document Type and Number:
Japanese Patent JPH0563468
Kind Code:
B2
Abstract:
Novel condensed seven-membered ring compounds of the formula: [wherein R<1> and R<2> are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or both jointly form tri- or tetramethylene; R<3> and R<5> are independently hydrogen lower alkyl or aralkyl; R<4> is hydrogen or lower alkyl; R<6> is a condensed or non-condensed hetero-alicyclic containing at least one atom of N, O and S as a ring-forming atom which may be substituted; A is an alkylene chain; n is 1 or 2] and salts thereof. These compounds exhibit inhibitory activity on angiotensin converting enzyme and so forth, and are of value as an agent for diagnosis, prevention and treatment of circulatory diseases, such as hypertension, cardiopathy and cerebral apoplexy.
Inventors:
SUGIHARA HIROSADA
NISHIKAWA KOHEI
ITO KATSUMI
NISHIKAWA KOHEI
ITO KATSUMI
Application Number:
JP11807089A
Publication Date:
September 10, 1993
Filing Date:
May 10, 1989
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
A61K31/445; A61K31/55; A61K31/554; A61P9/12; C07D209/48; C07D211/18; C07D211/22; C07D211/32; C07D281/10; C07D417/04; C07D417/12; C07K5/02; A61K38/00; (IPC1-7): C07D211/18; C07D211/32; C07D211/22
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