Japanese Patent JPH0566389

B2

Novel fused 7-membered ring compounds represented by formula (I) wherein R<1> and R<2> each represents hydrogen, halogen, tri-fluoromethyl, lower alkyl, alkoxy or, when taken together, they represent tri- or tetra-methylene, R<3> represents hydrogen, lower alkyl or aralkyl, R<4> represents hydrogen or optionally substituted alkyl, aralkyl or cycloalkyl, X represents S(O)n, where n is an integer of 0 to 2, Y represents optionally esterified or amidated carboxy, and m represents 1 or 2, and salts thereof are effective in inhibiting angiotensin-converting enzyme and are useful for diagnosis, prophylaxis and treatment of hypertension.

JP2013166781	USE OF CILOBRADINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT FOR TREATMENT OR PREVENTION OF HEART FAILURE
WO/1987/004430	FUSED BENZAZEPINES
JPS62187447	PRODUCTION OF THREO-2-HYDROXY-3-(4-METHOXYPHENYL)-3-(2-NITROPHENYLTHIO)-PROPIONIC ACID ESTER

SUGIHARA HIROSADA
NISHIKAWA KOHEI
ITO KATSUMI

JP1205385A

September 21, 1993

January 24, 1985

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TAKEDA CHEMICAL INDUSTRIES LTD

A61K31/55; A61K31/554; A61K38/00; A61P9/00; A61P9/12; A61P43/00; C07D209/48; C07D211/22; C07D211/34; C07D211/62; C07D213/55; C07D281/10; C07D309/06; C07D335/00; C07D335/02; C07D417/04; C07D417/12; C07K5/02; C07K5/06; C07K14/81; C12N9/99; (IPC1-7): C07D281/10; A61K31/55; A61K37/02; C07D417/12; C07K5/06

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