Title:
【発明の名称】脂肪族‐芳香族ケトン側鎖を含むペプチド
Document Type and Number:
Japanese Patent JPH0631315
Kind Code:
B2
Abstract:
GnRH peptide analogs which regulate the secretion of gonadotropins by the pituitary gland and either promote or inhibit the release of steroids by the gonads. Administration of an effective amount of a GnRH antagonist prevents ovulation of female mammalian eggs and/or the release of gonadotropins. Administration of GnRH agonists can be used to regulate fertility in male and female mammals.These and other peptide hormones exhibit improved binding efficiency and biological potency as a result having a residue in a critical, generally central location in the chain which residue contains a mixed alkyl ketone side-chain terminating in an aromatic group. Methods for efficiently synthesizing these peptides from readily available compounds are disclosed.
Inventors:
JAN EDOWAARU FUREDERITSUKU RIBEERU
HARII ARETSUKU ANDAASON
WAIRII UOOKAA BEERU JUNIA
HARII ARETSUKU ANDAASON
WAIRII UOOKAA BEERU JUNIA
Application Number:
JP3718086A
Publication Date:
April 27, 1994
Filing Date:
February 21, 1986
Export Citation:
Assignee:
SOOKU INST FUOO BAIOROJIKARU SUTADEIIZU ZA
International Classes:
A61K38/22; A61P5/00; C07K1/113; A61K38/04; C07K7/06; C07K7/23; C07K14/00; C07K14/575; A61K38/00; (IPC1-7): C07K7/06; C07K7/20
Domestic Patent References:
| JP5962556A | ||||
| JP56115753A |
Attorney, Agent or Firm:
Kyozo Yuasa (4 outside)
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