Title:
【発明の名称】ジペプタイド誘導体を含有する、筋萎縮性側索硬化症を治療するための薬剤
Document Type and Number:
Japanese Patent JPH0637395
Kind Code:
B2
Abstract:
A method of treating patients suffering from amyotrophic lateral sclerosis (ALS) by administering dipeptide derivatives of the formula wherein R1 is hydrogen, a lower alkyl group, cyclohexyl or benzyl; Z is one of the groups wherein if Z is a group (a), R2 and R3 together represent an additional bond between the carbon atoms bearing R2 and R3, or if Z is a group (b), R2 is hydrogen; R4 and R5 are hydrogen or lower alkyl, or R5 may also be phenyl; and R6 is hydrogen or methyl; hydrates or pharmaceutically acceptable acid additions salts thereof. Pharmaceutical compositions containing effective ALS symptom counteracting amounts of such dipeptide derivatives may be administered by infusion, injection, orally, rectally or percutaneously.
Inventors:
Leopold flohe
Hans Barth
Hans Barth
Application Number:
JP28213985A
Publication Date:
May 18, 1994
Filing Date:
December 17, 1985
Export Citation:
Assignee:
Gryunenthal, Gezershyaft, Mito, Bessylenktel, Haftung
International Classes:
A61K38/04; A61K38/00; A61K38/22; A61P25/00; (IPC1-7): A61K37/02
Domestic Patent References:
| JP49108075A | ||||
| JP52125166A | ||||
| JP5636442A |
Attorney, Agent or Firm:
Mitsuyoshi Ezaki (1 person outside)